Lu Lab

The Lu Lab is located in the Helen Diller Research Building at the UCSF Mission Bay campus in the Department of Neurological Surgery. Our lab focuses on identifying molecular mechanisms mediating immune suppression and evasion in brain tumors, with the goal of developing novel immunotherapeutics for these diseases.

 

 

Microglia
Macrophages and Microglia-mediated immunosuppression in glioblastoma

We investigate the mechanisms by which macrophages and microglia suppress immune response in the brain tumor microenvironment, with the goal to develop therapeutics to target this population.

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T cells
Cancer intrinsic mechanisms that mediate immune evasion in brain cancer

We are currently developing a novel immunotherapy to enhance immunogenicity of brain tumor, resulting in sensitizing to immune checkpoint blockade.

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PP2A protein crystal structure
PP2A as a novel immunotherapy target

We identified the role of PP2A in mediating tumor response, and are currently developing novel therapeutics targeting this enzyme. 

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