Cancer intrinsic mechanisms that mediate immune evasion in brain cancer

Brain cancers do not respond to immune checkpoint blockade, due to the intrinsic feature of low immunogenicity, leading to less T cell infiltration to the tumor. We are currently investigating how to enhance the immunogenicity of brain cancer, such as enhancing MHC-I expression, promoting Dendritic cells to present tumor antigens, resulting in T cells infiltration and sensitive to immune checkpoint blockade.