T cells

Cancer intrinsic mechanisms that mediate immune evasion in brain cancer

Brain cancers do not respond to immune checkpoint blockade, due to the intrinsic feature of low immunogenicity, leading to less T cell infiltration to the tumor. We are currently investigating how to enhance the immunogenicity of brain cancer, such as enhancing MHC-I expression, promoting Dendritic cells to present tumor antigens, resulting in T cells infiltration and sensitive to immune checkpoint blockade.