Macrophages and Microglia-mediated immunosuppression in glioblastoma

Tumor associated macrophages and microglia (TAMs) compose about 40% of tumor mass of glioblastoma (GBM) and are thought to be the primary drivers of immunosuppression. Interestingly, previous studies have demonstrated that the depletion of macrophages does not clinically benefit GBM, but TAMs are highly plastic and can become highly immunostimulatory. We have identified a novel mechanism by which TAMs mediate immunosuppression, and we are developing novel TAMs targeting strategies.