Lab bench with Falcon conical tubes and test tubes

Research

The goal of the Lu Lab is to understand the molecular mechanisms mediating immune suppression in brain tumors to aid in the development of novel immunotherapeutics. 

 

 

Microglia
Macrophages and Microglia-mediated Immune Evasion

We investigate the mechanisms by which macrophages and microglia suppress immune response in the brain tumor microenvironment, with the goal to develop therapeutics to target this population.

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T cells
Cancer intrinsic mechanisms that mediate immune evasion in brain cancer

We are currently developing a novel immunotherapy to enhance immunogenicity of brain tumor, resulting in sensitizing to immune checkpoint blockade.

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PP2A protein crystal structure
PP2A as a novel immunotherapy target

We identified the role of PP2A in mediating tumor response and are currently developing novel therapeutics targeting this enzyme. 

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