Chao Gao, PhD
Research interests: targeting PP2A for immunotherapy; the mechanisms of macrophage-mediated immune evasion
As a postdoctoral researcher, my work focuses on investigating the mechanisms behind macrophage-induced immunosuppression in brain tumors and exploring potential therapeutic targets and strategies for clinical application. Additionally, I also interested in developing novel therapeutics targeting PP2A.
I received my PhD training from Fudan University, where I employed immunology techniques and multi-omics analysis to study the role of metabolism in macrophages, as well as using molecular and cell biology approaches to study how metabolism and epigenetics influence tumor cells.
Outside the lab, I enjoy cooking, photography and doing aerobics.
The Zscan4-Tet2 Transcription Nexus Regulates Metabolic Rewiring and Enhances Proteostasis to Promote Reprogramming.
Cheng ZL, Zhang ML, Lin HP, Gao C, Song JB, Zheng Z, Li L, Zhang Y, Shen X, Zhang H, Huang Z, Zhan W, Zhang C, Hu X, Sun YP, Jiang L, Sun L, Xu Y, Yang C, Ge Y, Zhao Y, Liu X, Yang H, Liu P, Guo X, Guan KL, Xiong Y, Zhang M, Ye D.
Cell Rep. 2020 Jul 14;32(2):107877. doi: 10.1016/j.celrep.2020.107877. PMID: 32668244.
Tumor suppressor CEBPA interacts with and inhibits DNMT3A activity.
Chen X, Zhou W, Song RH, Liu S, Wang S, Chen Y, Gao C, He C, Xiao J, Zhang L, Wang T, Liu P, Duan K, Cheng Z, Zhang C, Zhang J, Sun Y, Jackson F, Lan F, Liu Y, Xu Y, Wong JJ, Wang P, Yang H, Xiong Y, Chen T, Li Y, Ye D.
Sci Adv. 2022 Jan 28;8(4):eabl5220. doi: 10.1126/sciadv.abl5220. Epub 2022 Jan 26. PMID: 35080973; PMCID: PMC8791617.